Memory reactivation in rat medial prefrontal cortex occurs in a subtype of cortical UP state during slow-wave sleep

Memory stabilization with targeted reactivation during human slow-wave sleep.

It is believed that neural representations of recent experiences become reactivated during sleep, and that this process serves to stabilize associated memories in long-term memory. Here, we initiated this reactivation process for specific memories during slow-wave sleep. Participants studied 50 object-location associations with object-related sounds presented concurrently. For half of the assoc...

Stored-trace reactivation in rat prefrontal cortex is correlated with down-to-up state fluctuation density.

Spontaneous reactivation of previously stored patterns of neural activity occurs in hippocampus and neocortex during non-rapid eye movement (NREM) sleep. Notable features of the neocortical local field potential during NREM sleep are high-amplitude, low-frequency thalamocortical oscillations including K-complexes, low-voltage spindles, and high-voltage spindles. Using combined neuronal ensemble...

Cued memory reactivation during slow-wave sleep promotes explicit knowledge of a motor sequence.

Memories are gradually consolidated after initial encoding, and this can sometimes lead to a transition from implicit to explicit knowledge. The exact physiological processes underlying this reorganization remain unclear. Here, we used a serial reaction time task to determine whether targeted memory reactivation (TMR) of specific memory traces during slow-wave sleep promotes the emergence of ex...

prelimbic of medial prefrontal cortex GABA modulation through testosterone on spatial learning and memory

Prefrontal cortex (PFC) is involved in multiple functions including attentional , spatial orientation, short and long-term memory. Our previous study indicated that microinjection of testosterone in CA1 impaired spatial learning and memory. Some evidence suggests that impairment effect of testosterone is mediated by GABAergic system. In the present study, we investigated the interaction of test...

Cued reactivation during slow-wave sleep induces connectivity changes related to memory stabilization